Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities

• Main Authors: Jiangseubchatveera N., Bouillon M.E., Liawruangrath B., Liawruangrath S., Nash R.J., Pyne S.G.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884564713&partnerID=40&md5=6b79c1d7dbf6c4e1824089596fd30b86; http://cmuir.cmu.ac.th/handle/6653943832/4418
• Institution: Chiang Mai University

A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL-1 concentrations) and were found to have in general poor inhibitory act...