Development of Krabok (Irvingia malayana) wax as a suppository base

Krabok (Irvingia malayana) wax was modified to obtain elasticity and good releasing medicament suppository bases by mixing with compounds such as vegetable oils, mineral oil, fatty acids and semi-synthetic waxes in various proportions to produce bases with melting range of 33-37°C. Compounds which p...

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Main Authors: Sirisa-Ard P., Piyamongkol S., Charumanee S., Yotsawimonwat S., Pholsongkram K.
Format: Conference or Workshop Item
Language:English
Published: International Society for Horticultural Science 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84899521530&partnerID=40&md5=45196adec1725f98c4a21d225baaabf0
http://cmuir.cmu.ac.th/handle/6653943832/4422
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-44222014-08-30T02:42:21Z Development of Krabok (Irvingia malayana) wax as a suppository base Sirisa-Ard P. Piyamongkol S. Charumanee S. Yotsawimonwat S. Pholsongkram K. Krabok (Irvingia malayana) wax was modified to obtain elasticity and good releasing medicament suppository bases by mixing with compounds such as vegetable oils, mineral oil, fatty acids and semi-synthetic waxes in various proportions to produce bases with melting range of 33-37°C. Compounds which passed the screening tests including rice bran oil, mineral oil (heavy), Span 20, cotton seed oil and polyethylene glycol (PEG) 40 stearate were combined with wax and prepared as suppositories. Drug released study demonstrated that wax with 15% cotton seed oil and 15% PEG 40 stearate was the best in releasing diclofenac into the medium. All wax mixtures become harder after three months storage together with darker color and white surface coating. Moreover, wax mixed with oleic acid gave the lowest onset temperature of melting point. From all information obtained, 11 formulae were prepared and tested for their suitability as systemic suppository bases. Only 3 formulae were chosen and re-prepared with the addition of 5% diclofenac sodium. All formulae were too soft (<600 g) when compared to Witepsol W35. Formula 9, containing 70% wax, 15% cotton seed oil and 15% oleic acid, was the slowest to disintegrate which was due to the absence of surfactant in its formula. However, formula 9 released twice the amount of diclofenac into the medium when compared to that of Witepsol W35 and Formula 7 gave similar drug released pattern as that of Witepsol W35. Suggestion for further study is to improve the hardness of the base to 2-3 kg to withstand the break forces caused by various types of handlings i.e. production, packaging, shipping and patient in-use. © ISHS. 2014-08-30T02:42:21Z 2014-08-30T02:42:21Z 2014 Conference Paper 9789462610149 05677572 http://www.scopus.com/inward/record.url?eid=2-s2.0-84899521530&partnerID=40&md5=45196adec1725f98c4a21d225baaabf0 http://cmuir.cmu.ac.th/handle/6653943832/4422 English International Society for Horticultural Science
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Krabok (Irvingia malayana) wax was modified to obtain elasticity and good releasing medicament suppository bases by mixing with compounds such as vegetable oils, mineral oil, fatty acids and semi-synthetic waxes in various proportions to produce bases with melting range of 33-37°C. Compounds which passed the screening tests including rice bran oil, mineral oil (heavy), Span 20, cotton seed oil and polyethylene glycol (PEG) 40 stearate were combined with wax and prepared as suppositories. Drug released study demonstrated that wax with 15% cotton seed oil and 15% PEG 40 stearate was the best in releasing diclofenac into the medium. All wax mixtures become harder after three months storage together with darker color and white surface coating. Moreover, wax mixed with oleic acid gave the lowest onset temperature of melting point. From all information obtained, 11 formulae were prepared and tested for their suitability as systemic suppository bases. Only 3 formulae were chosen and re-prepared with the addition of 5% diclofenac sodium. All formulae were too soft (<600 g) when compared to Witepsol W35. Formula 9, containing 70% wax, 15% cotton seed oil and 15% oleic acid, was the slowest to disintegrate which was due to the absence of surfactant in its formula. However, formula 9 released twice the amount of diclofenac into the medium when compared to that of Witepsol W35 and Formula 7 gave similar drug released pattern as that of Witepsol W35. Suggestion for further study is to improve the hardness of the base to 2-3 kg to withstand the break forces caused by various types of handlings i.e. production, packaging, shipping and patient in-use. © ISHS.
format Conference or Workshop Item
author Sirisa-Ard P.
Piyamongkol S.
Charumanee S.
Yotsawimonwat S.
Pholsongkram K.
spellingShingle Sirisa-Ard P.
Piyamongkol S.
Charumanee S.
Yotsawimonwat S.
Pholsongkram K.
Development of Krabok (Irvingia malayana) wax as a suppository base
author_facet Sirisa-Ard P.
Piyamongkol S.
Charumanee S.
Yotsawimonwat S.
Pholsongkram K.
author_sort Sirisa-Ard P.
title Development of Krabok (Irvingia malayana) wax as a suppository base
title_short Development of Krabok (Irvingia malayana) wax as a suppository base
title_full Development of Krabok (Irvingia malayana) wax as a suppository base
title_fullStr Development of Krabok (Irvingia malayana) wax as a suppository base
title_full_unstemmed Development of Krabok (Irvingia malayana) wax as a suppository base
title_sort development of krabok (irvingia malayana) wax as a suppository base
publisher International Society for Horticultural Science
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84899521530&partnerID=40&md5=45196adec1725f98c4a21d225baaabf0
http://cmuir.cmu.ac.th/handle/6653943832/4422
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