Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone

Curcumin has been extensively reported as a potential natural antioxidant. However, there was no data on activity comparison as well as the biological interactions of curcumin with other natural antioxidants. The aim of the present study was to investigate the antioxidant power of curcumin in compar...

Full description

Saved in:
Bibliographic Details
Main Authors: Ornchuma Naksuriya, Siriporn Okonogi
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964698043&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44367
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-44367
record_format dspace
spelling th-cmuir.6653943832-443672018-04-25T07:49:00Z Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone Ornchuma Naksuriya Siriporn Okonogi Agricultural and Biological Sciences Curcumin has been extensively reported as a potential natural antioxidant. However, there was no data on activity comparison as well as the biological interactions of curcumin with other natural antioxidants. The aim of the present study was to investigate the antioxidant power of curcumin in comparison with three important natural antioxidants; gallic acid, ascorbic acid, and xanthone on free radical scavenging action and their combination effects on this activity. The results indicated that the activities of these compounds were dose-dependent. The 50% effective concentration (EC50) of curcumin was found to be 11 μg/mL. Curcumin showed significantly higher antioxidant activity than ascorbic acid and xanthone but less than gallic acid. Interestingly, curcumin revealed synergistic antioxidant effect when combined with gallic acid whereas the antagonistic effect occurred in curcumin combination with ascorbic acid or xanthone. These results suggest that curcumin-gallic acid combination is the potential antioxidant mixture to be used in place of the individual substance whereas using of curcumin in combination with ascorbic acid or xanthone should be avoid. 2018-01-24T04:41:37Z 2018-01-24T04:41:37Z 2015-04-01 Journal 18817831 2-s2.0-84964698043 10.5582/ddt.2015.01013 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964698043&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44367
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
spellingShingle Agricultural and Biological Sciences
Ornchuma Naksuriya
Siriporn Okonogi
Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
description Curcumin has been extensively reported as a potential natural antioxidant. However, there was no data on activity comparison as well as the biological interactions of curcumin with other natural antioxidants. The aim of the present study was to investigate the antioxidant power of curcumin in comparison with three important natural antioxidants; gallic acid, ascorbic acid, and xanthone on free radical scavenging action and their combination effects on this activity. The results indicated that the activities of these compounds were dose-dependent. The 50% effective concentration (EC50) of curcumin was found to be 11 μg/mL. Curcumin showed significantly higher antioxidant activity than ascorbic acid and xanthone but less than gallic acid. Interestingly, curcumin revealed synergistic antioxidant effect when combined with gallic acid whereas the antagonistic effect occurred in curcumin combination with ascorbic acid or xanthone. These results suggest that curcumin-gallic acid combination is the potential antioxidant mixture to be used in place of the individual substance whereas using of curcumin in combination with ascorbic acid or xanthone should be avoid.
format Journal
author Ornchuma Naksuriya
Siriporn Okonogi
author_facet Ornchuma Naksuriya
Siriporn Okonogi
author_sort Ornchuma Naksuriya
title Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
title_short Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
title_full Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
title_fullStr Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
title_full_unstemmed Comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
title_sort comparison and combination effects on antioxidant power of curcumin with gallic acid, ascorbic acid, and xanthone
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84964698043&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44367
_version_ 1681422546342248448