Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems

The aim of this work was to investigate the suitable rice varieties for developing pharmaceutical buccal films. Two rice varieties with extreme difference in amylose content were used. Rice powders were chemically modified to yield the carboxymethyl rice prior to film preparation. Scanning electron...

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Main Authors: Siriporn Okonogi, Sakornrat Khongkhunthian, Sanchai Jaturasitha
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930513322&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44935
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-449352018-01-24T06:01:38Z Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems Siriporn Okonogi Sakornrat Khongkhunthian Sanchai Jaturasitha The aim of this work was to investigate the suitable rice varieties for developing pharmaceutical buccal films. Two rice varieties with extreme difference in amylose content were used. Rice powders were chemically modified to yield the carboxymethyl rice prior to film preparation. Scanning electron microscope (SEM) and X-ray diffractometer (XRD) were used to investigate the solid structure of rice powders. The results indicated that amylose content in the rice grains played the effects on the morphology and crystalline structure of the modified rice powders as well as the film properties. The modified rice powders of low amylose content showed halo pattern XRD whereas some crystalline peaks could be observed from the high amylose content modified rice powders. Adding of glycerin caused the films better properties of more transparency and getting rid of air bubbles. High amylose rice films showed more transparency and higher mucoadhesive property and was considered to be suitable for incorporating the drug. Adding of surfactant caused the increase in tensile strength and decrease in elongation of the rice films. The most suitable surfactant for diclofenac buccal rice film is Tween 20. This study demonstrates that rice grains are the promising natural source for pharmaceutical film forming agent. Suitable pharmaceutical buccal films could be developed from the rice with high amylose content. 2018-01-24T06:01:38Z 2018-01-24T06:01:38Z 2014-12-01 Journal 18817831 2-s2.0-84930513322 10.5582/ddt.2014.01041 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930513322&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/44935
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description The aim of this work was to investigate the suitable rice varieties for developing pharmaceutical buccal films. Two rice varieties with extreme difference in amylose content were used. Rice powders were chemically modified to yield the carboxymethyl rice prior to film preparation. Scanning electron microscope (SEM) and X-ray diffractometer (XRD) were used to investigate the solid structure of rice powders. The results indicated that amylose content in the rice grains played the effects on the morphology and crystalline structure of the modified rice powders as well as the film properties. The modified rice powders of low amylose content showed halo pattern XRD whereas some crystalline peaks could be observed from the high amylose content modified rice powders. Adding of glycerin caused the films better properties of more transparency and getting rid of air bubbles. High amylose rice films showed more transparency and higher mucoadhesive property and was considered to be suitable for incorporating the drug. Adding of surfactant caused the increase in tensile strength and decrease in elongation of the rice films. The most suitable surfactant for diclofenac buccal rice film is Tween 20. This study demonstrates that rice grains are the promising natural source for pharmaceutical film forming agent. Suitable pharmaceutical buccal films could be developed from the rice with high amylose content.
format Journal
author Siriporn Okonogi
Sakornrat Khongkhunthian
Sanchai Jaturasitha
spellingShingle Siriporn Okonogi
Sakornrat Khongkhunthian
Sanchai Jaturasitha
Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
author_facet Siriporn Okonogi
Sakornrat Khongkhunthian
Sanchai Jaturasitha
author_sort Siriporn Okonogi
title Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
title_short Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
title_full Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
title_fullStr Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
title_full_unstemmed Development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
title_sort development of mucoadhesive buccal films from rice for pharmaceutical delivery systems
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84930513322&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/44935
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