Pairwise decomposition of residue interaction energies of single chain Fv with HIV-1 p17 epitope variants

• Main Authors: Lee V.S., Tue-ngeun P., Nangola S., Kitidee K., Jitonnom J., Nimmanpipug P., Jiranusornkul S., Tayapiwatana C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-74849100500&partnerID=40&md5=acad915889f934bbd78c581e119dab1b; http://www.ncbi.nlm.nih.gov/pubmed/20022377; http://cmuir.cmu.ac.th/handle/6653943832/4509
• Institution: Chiang Mai University

Computational assisted modeling was carried out to investigate the importance of specific residues in the binding site of scFv. In this study, scFv against HIV-1 epitope at the C-terminal on p17 (scFv anti-p17) was used as a candidate molecule for evaluating the method. The wild-type p17 and its nin...