Chemical stability enhancement and cytotoxicity reduction of papain loaded in PLGA nanospheres

• Main Authors: Charinya Chankhampan, Jiradej Manosroi, Hiromitsu Yamamoto, Kohei Tahara, Worapaka Manosroi, Yoshiaki Kawashima, Aranya Manosroi
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891533280&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/45185
• Institution: Chiang Mai University

Poly(lactic-co-glycolic acid) (PLGA) nanospheres loaded with papain were prepared by the emulsion solvent diffusion in water (ESD) and the w/o/w emulsion solvent evaporation (ESE) methods. The nanosphere loaded with papain from the ESE method gave smaller particle sizes (220-232 nm) and higher encap...