VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction

• Main Authors: Chee Wah Tan, I. Ching Sam, Vannajan Sanghiran Lee, Hui Vern Wong, Yoke Fun Chan
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995877456&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/46962
• Institution: Chiang Mai University

© 2016 Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K1...