TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo

• Main Authors: Warangkana Arpornchayanon, Martin Canis, Friedrich Ihler, Claudia Settevendemie, Sebastian Strieth
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880117258&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/47780
• Institution: Chiang Mai University

Objective: Exposure to loud noise can impair cochlear microcirculation and cause noise-induced hearing loss (NIHL). TNF-α signaling has been shown to be activated in NIHL and to control spiral modiolar artery vasoconstriction that regulates cochlear microcirculation. It was the aim of this experime...