Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla
Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited an...
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| Main Authors: | , , |
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| Format: | Journal |
| Published: |
2018
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| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876930059&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47997 |
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| Institution: | Chiang Mai University |
| Summary: | Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC 50 of 7.6 μM. © 2013 The American Chemical Society and American Society of Pharmacognosy. |
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