Concise synthesis of α-substituted 2-benzofuranmethamines and other 2-subsituted benzofurans via α-substituted 2-benzofuranmethyl carbocation intermediates
Propargyl amines 4, where R 3 is aryl, undergo 5-exo-dig cyclization reactions under relatively mild conditions (AgNO 3 , DMF, 60 C, 1 h) to give 3-amino-2,3-dihydro-2-arylmethylidenebenzofurans 5 (R 3 = aryl). In contrast, substrates where R 3 is alkyl undergo competing 6-endo-dig and 5-exo-dig...
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| Main Authors: | , , , , , , , |
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| Format: | Journal |
| Published: |
2018
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| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873325933&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48139 |
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| Institution: | Chiang Mai University |