Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides
Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct r...
محفوظ في:
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Royal Society of Chemistry
2014
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| الوصول للمادة أونلاين: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84901257342&partnerID=40&md5=5f540c448117745de4f25aa373ff4cec http://cmuir.cmu.ac.th/handle/6653943832/4830 |
| الوسوم: |
إضافة وسم
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| المؤسسة: | Chiang Mai University |
| اللغة: | English |
| الملخص: | Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct reductive amination with amines using sodium borohydride and montmorillonite K-10 catalyst as the reducing system. This green and simple procedure enables N-alkylated amines to be prepared in good to excellent yields with high selectivity of the monoalkylation. This journal is © the Partner Organisations 2014. |
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