Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides
Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct r...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2014
|
| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84901257342&partnerID=40&md5=5f540c448117745de4f25aa373ff4cec http://cmuir.cmu.ac.th/handle/6653943832/4830 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Chiang Mai University |
| Language: | English |
| id |
th-cmuir.6653943832-4830 |
|---|---|
| record_format |
dspace |
| spelling |
th-cmuir.6653943832-48302014-08-30T02:55:50Z Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides Khumraksa B. Phakhodee W. Pattarawarapan M. Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct reductive amination with amines using sodium borohydride and montmorillonite K-10 catalyst as the reducing system. This green and simple procedure enables N-alkylated amines to be prepared in good to excellent yields with high selectivity of the monoalkylation. This journal is © the Partner Organisations 2014. 2014-08-30T02:55:50Z 2014-08-30T02:55:50Z 2014 Article 20462069 10.1039/c4ra02969k RSCAC http://www.scopus.com/inward/record.url?eid=2-s2.0-84901257342&partnerID=40&md5=5f540c448117745de4f25aa373ff4cec http://cmuir.cmu.ac.th/handle/6653943832/4830 English Royal Society of Chemistry |
| institution |
Chiang Mai University |
| building |
Chiang Mai University Library |
| country |
Thailand |
| collection |
CMU Intellectual Repository |
| language |
English |
| description |
Ultrasound-assisted solventless oxidation/reductive amination of benzyl halides was developed as a facile, efficient, and environmental friendly method toward N-alkylated amines. Aldehydes were formed in situ by oxidation of organic halides with N-methylmorpholine N-oxide (NMO), followed by direct reductive amination with amines using sodium borohydride and montmorillonite K-10 catalyst as the reducing system. This green and simple procedure enables N-alkylated amines to be prepared in good to excellent yields with high selectivity of the monoalkylation. This journal is © the Partner Organisations 2014. |
| format |
Article |
| author |
Khumraksa B. Phakhodee W. Pattarawarapan M. |
| spellingShingle |
Khumraksa B. Phakhodee W. Pattarawarapan M. Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| author_facet |
Khumraksa B. Phakhodee W. Pattarawarapan M. |
| author_sort |
Khumraksa B. |
| title |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_short |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_full |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_fullStr |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_full_unstemmed |
Ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| title_sort |
ultrasound-assisted solventless synthesis of amines by in situ oxidation/reductive amination of benzyl halides |
| publisher |
Royal Society of Chemistry |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84901257342&partnerID=40&md5=5f540c448117745de4f25aa373ff4cec http://cmuir.cmu.ac.th/handle/6653943832/4830 |
| _version_ |
1681420311073914880 |