Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities
A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL < sup > -1 < /sup > concentrations) and were found to have...
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2018
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th-cmuir.6653943832-483032018-04-25T08:50:19Z Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities Nadechanok Jiangseubchatveera Marc E. Bouillon Boonsom Liawruangrath Saisunee Liawruangrath Robert J. Nash Stephen G. Pyne A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL < sup > -1 < /sup > concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50-54% inhibition of α-l-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-d-glucosaminidase (from Jack bean) at the same concentration (760 μM). © The Royal Society of Chemistry 2013. 2018-04-25T08:50:19Z 2018-04-25T08:50:19Z 2013-01-01 Journal 14770520 2-s2.0-84884564713 10.1039/c3ob40374b https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884564713&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48303 |
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A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL < sup > -1 < /sup > concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50-54% inhibition of α-l-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-d-glucosaminidase (from Jack bean) at the same concentration (760 μM). © The Royal Society of Chemistry 2013. |
| format |
Journal |
| author |
Nadechanok Jiangseubchatveera Marc E. Bouillon Boonsom Liawruangrath Saisunee Liawruangrath Robert J. Nash Stephen G. Pyne |
| spellingShingle |
Nadechanok Jiangseubchatveera Marc E. Bouillon Boonsom Liawruangrath Saisunee Liawruangrath Robert J. Nash Stephen G. Pyne Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| author_facet |
Nadechanok Jiangseubchatveera Marc E. Bouillon Boonsom Liawruangrath Saisunee Liawruangrath Robert J. Nash Stephen G. Pyne |
| author_sort |
Nadechanok Jiangseubchatveera |
| title |
Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| title_short |
Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| title_full |
Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| title_fullStr |
Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| title_full_unstemmed |
Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| title_sort |
concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities |
| publishDate |
2018 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884564713&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48303 |
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1681423224370364416 |