Involvement of the P2X<inf>7</inf>purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E<inf>2</inf>induction by LL-37

• Main Authors: Pareena Chotjumlong, Jan G. Bolscher, Kamran Nazmi, Vichai Reutrakul, Chayarop Supanchart, Worakanya Buranaphatthana, Suttichai Krisanaprakornkit
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872276132&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/48338
• Institution: Chiang Mai University

Periodontal disease is caused by microorganisms and host-derived inflammation involving increased cyclooxygenase-2 (COX-2) expression and prostaglandin E 2 (PGE 2 ) production. We previously demonstrated that human β-defensin-3 induces COX-2 and PGE 2 in human gingival fibroblasts (HGFs). We, theref...