Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents

• Main Authors: Silvia Dei, Marcella Coronnello, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Chatchanok Udomtanakunchai, Milena Salerno, Elisabetta Teodori
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041407631&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/48477
• Institution: Chiang Mai University

© 2018 Elsevier Masson SAS A series of 1,4-substituted arylalkyl piperazine derivatives were synthesized and studied with the aim to obtain potent P-gp-dependent multidrug-resistant (MDR) reversers. The new compounds were designed on the basis of the structures of our previous arylamine ester deriva...