Combined iron chelator and T-type calcium channel blocker exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice

• Main Authors: Sirinart Kumfu, Juthamas Khamseekaew, Siripong Palee, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C. Chattipakorn, Nipon Chattipakorn
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041664105&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/48485
• Institution: Chiang Mai University

© 2018 Elsevier B.V. Although both iron chelators and T-type calcium channel (TTCC) blockers have been shown to exert cardioprotection by decreasing cardiac iron deposition and reducing left ventricular (LV) dysfunction via different channels in iron-overloaded rodent models, the cardioprotective ef...