Analysis of pharmaceutical heparins and potential contaminants using¹H-NMR and PAGE

• المؤلفون الرئيسيون: Zhenqing Zhang, Boyangzi Li, Jiraporn Suwan, Fuming Zhang, Zhenyu Wang, Haiying Liu, Barbara Mulloy, Robert J. Linhardt
• التنسيق: دورية
• منشور في: 2018
• الموضوعات: Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349648765&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49434
• المؤسسة: Chiang Mai University

In 2008, heparin (active pharmaceutical ingredient, API) lots were associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthetic glycosaminoglycan (GAG), was identified as a contaminant and dermatan sulfate (DS) as an impurity. While DS has no known toxicity...