Analysis of pharmaceutical heparins and potential contaminants using<sup>1</sup>H-NMR and PAGE

In 2008, heparin (active pharmaceutical ingredient, API) lots were associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthetic glycosaminoglycan (GAG), was identified as a contaminant and dermatan sulfate (DS) as an impurity. While DS has no known toxicity...

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Bibliographic Details
Main Authors: Zhenqing Zhang, Boyangzi Li, Jiraporn Suwan, Fuming Zhang, Zhenyu Wang, Haiying Liu, Barbara Mulloy, Robert J. Linhardt
Format: Journal
Published: 2018
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Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349648765&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49434
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Institution: Chiang Mai University
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