Inhibitory effect of caffeic acid and its derivatives on human liver cytochrome P450 3A4 activity

Inhibitory effect of caffeic acid and its derivatives on human liver cytochrome P450 3A4 activity

Effects of caffeic acid (CAF) and its derivatives on human liver CYP3A4 activity were evaluated by using diazepam as a substrate. It was found that CAF inhibited CYP3A4 activity by uncompetitive inhibition with IC50 0.72 μM, whereas ester and amide analogues inhibited CYP3A4 by competitive inhibitio...

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Bibliographic Details
Main Authors: Churdsak Jaikang, Kanokporn Niwatananun, Paitoon Narongchai, Siripun Narongchai, Chaiyavat Chaiyasut
Format: Journal
Published: 2018
Subjects:
Agricultural and Biological Sciences
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860417144&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49579
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Institution: Chiang Mai University

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860417144&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49579

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