Inhibitory effect of caffeic acid and its derivatives on human liver cytochrome P450 3A4 activity
Effects of caffeic acid (CAF) and its derivatives on human liver CYP3A4 activity were evaluated by using diazepam as a substrate. It was found that CAF inhibited CYP3A4 activity by uncompetitive inhibition with IC50 0.72 μM, whereas ester and amide analogues inhibited CYP3A4 by competitive inhibitio...
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| Main Authors: | , , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860417144&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49579 |
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| Institution: | Chiang Mai University |