Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders

Aim The effects of estrogen on the prevention of impaired insulin-induced long-term depression in the hippocampus and neuronal insulin signaling caused by high-fat diet (HF) were studied in male and female rats. Main methods Both male and female rats were fed with a normal diet (ND; 19.7% energy fro...

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Main Authors: Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C. Chattipakorn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/49671
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spelling th-cmuir.6653943832-496712018-09-04T04:28:42Z Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders Wasana Pratchayasakul Nipon Chattipakorn Siriporn C. Chattipakorn Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics Aim The effects of estrogen on the prevention of impaired insulin-induced long-term depression in the hippocampus and neuronal insulin signaling caused by high-fat diet (HF) were studied in male and female rats. Main methods Both male and female rats were fed with a normal diet (ND; 19.7% energy from fat) or a high-fat diet (HF; 59.3% energy from fat) for 12 weeks. Then, rats were divided into four subgroups: ND, ND + E, HF and HF + E. The subgroups with + E were given 50 μg/kg estrogen subcutaneously once a day for 30 days. At the end of the experimental period, blood and brain samples were collected to determine the peripheral insulin resistance and neuronal insulin resistance, respectively. Key findings Both male and female rats fed with HF developed peripheral insulin resistance as indicated by increased body weight, visceral fat, plasma insulin and HOMA index. Estrogen administration decreased those parameters, indicating improved peripheral insulin sensitivity, in both male and female HF rats. HF diet consumption also caused impaired insulin-induced long-term depression in hippocampus and impaired neuronal insulin receptor function and signaling, indicating neuronal insulin resistance, in both male and female rats. Estrogen treatment could attenuate these neuronal impairments only in HF female rats. Significance The activation of the estrogen pathway could preserve insulin sensitivity in the peripheral tissue in both male and female rats. In neuronal tissue, however, the benefit of estrogen could be found only in female rats. © 2011 Elsevier Inc. 2018-09-04T04:05:20Z 2018-09-04T04:05:20Z 2011-11-07 Journal 18790631 00243205 2-s2.0-80054987658 10.1016/j.lfs.2011.08.011 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054987658&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49671
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Wasana Pratchayasakul
Nipon Chattipakorn
Siriporn C. Chattipakorn
Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
description Aim The effects of estrogen on the prevention of impaired insulin-induced long-term depression in the hippocampus and neuronal insulin signaling caused by high-fat diet (HF) were studied in male and female rats. Main methods Both male and female rats were fed with a normal diet (ND; 19.7% energy from fat) or a high-fat diet (HF; 59.3% energy from fat) for 12 weeks. Then, rats were divided into four subgroups: ND, ND + E, HF and HF + E. The subgroups with + E were given 50 μg/kg estrogen subcutaneously once a day for 30 days. At the end of the experimental period, blood and brain samples were collected to determine the peripheral insulin resistance and neuronal insulin resistance, respectively. Key findings Both male and female rats fed with HF developed peripheral insulin resistance as indicated by increased body weight, visceral fat, plasma insulin and HOMA index. Estrogen administration decreased those parameters, indicating improved peripheral insulin sensitivity, in both male and female HF rats. HF diet consumption also caused impaired insulin-induced long-term depression in hippocampus and impaired neuronal insulin receptor function and signaling, indicating neuronal insulin resistance, in both male and female rats. Estrogen treatment could attenuate these neuronal impairments only in HF female rats. Significance The activation of the estrogen pathway could preserve insulin sensitivity in the peripheral tissue in both male and female rats. In neuronal tissue, however, the benefit of estrogen could be found only in female rats. © 2011 Elsevier Inc.
format Journal
author Wasana Pratchayasakul
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_facet Wasana Pratchayasakul
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_sort Wasana Pratchayasakul
title Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
title_short Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
title_full Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
title_fullStr Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
title_full_unstemmed Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
title_sort effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054987658&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49671
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