Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1

• Main Authors: Kanokkarn Phromnoi, Sahdeo Prasad, Subash Gupta, Ramaswamy Kannappan, Simone Reuter, Pornngarm Limtrakul, Bharat B. Aggarwal
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80054782411&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49674
• Institution: Chiang Mai University

Because constitutive activation of signal transducers and activators of transcription-3 (STAT3) has been linked with cellular transformation, survival, proliferation, chemoresistance, and angiogenesis of various tumor cells, agents that can suppress STAT3 activation have potential as cancer therapeu...