Inhibitory mechanism of pure curcumin on Wilms' tumor 1 (WT1) gene expression through the PKCα signaling pathway in leukemic K562 cells

• Main Authors: Suwanna Semsri, Sheryl R. Krig, Lakmal Kotelawala, Colleen A. Sweeney, Songyot Anuchapreeda
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960383409&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49701
• Institution: Chiang Mai University

The aim of this study was to investigate the inhibitory mechanism of pure curcumin on WT1 expression in leukemic K562 cells. Pure curcumin suppressed WT1 expression, independent of effects on protein degradation or WT1 mRNA stability. Chromatin immunoprecipitation and reporter gene assays indicate t...