Clausenawallines A and B, two new dimeric carbazole alkaloids from the roots of Clausena wallichii

Clausenawallines A and B, two new dimeric carbazole alkaloids from the roots of Clausena wallichii

Two new dimeric carbazole alkaloids, clausenawallines A and B, were isolated from the roots of Clausena wallichii. Their structures were elucidated by spectroscopic methods. Clausenawalline A was evaluated for its biological activities [anti-malaria (IC502.46 μg/mL), anti-TB (MIC 12.50 μg/mL)] and c...

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Bibliographic Details
Main Authors: Wisanu Maneerat, Thunwadee Ritthiwigrom, Sarot Cheenpracha, Uma Prawat, Surat Laphookhieo
Format: Journal
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79957607206&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49706
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Institution: Chiang Mai University
Description
Summary:Two new dimeric carbazole alkaloids, clausenawallines A and B, were isolated from the roots of Clausena wallichii. Their structures were elucidated by spectroscopic methods. Clausenawalline A was evaluated for its biological activities [anti-malaria (IC502.46 μg/mL), anti-TB (MIC 12.50 μg/mL)] and cytotoxicity against three human cancer cell lines [KB (IC507.87 μg/mL), MCF7 (IC5025.43 μg/mL), and NCI-H187 (IC5010.97 μg/mL)]. © 2011 Elsevier Ltd. All rights reserved.

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