Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models

• Main Authors: Y. Liu, S. Tuve, J. Persson, I. Beyer, R. Yumul, Z. Y. Li, K. Tragoolpua, K. E. Hellström, S. Roffler, A. Lieber
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79956110698&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49712
• Institution: Chiang Mai University

Tumor-associated antigens (TAAs) include overexpressed self-antigens (for example, Her2/neu) and tumor virus antigens (for example, HPV-16 E6/E7). Although in cancer patients, TAA-specific CD4+ and CD8+ cells are often present, they are not able to control tumor growth. In recent studies, it became...