Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres

• Main Authors: Pavel Plevka, Anthony J. Battisti, Jiraphan Junjhon, Dennis C. Winkler, Heather A. Holdaway, Poonsook Keelapang, Nopporn Sittisombut, Richard J. Kuhn, Alasdair C. Steven, Michael G. Rossmann
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79957981824&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49715
• Institution: Chiang Mai University

Flaviviruses assemble as fusion-incompetent immature particles and subsequently undergo conformational change leading to release of infectious virions. Flavivirus infections also produce combined mosaic particles. Here, using cryo-electron tomography, we report that mosaic particles of dengue virus...