5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid

The three crude extracts including Oryza sativa (bran) from supercritical carbon dioxide fluid (scCO2) process which gave the highest unsaturated fatty acid contents and biological activities including the antioxidative, tyrosinase inhibition, stimulation index on human normal skin fibroblast were s...

Full description

Saved in:
Bibliographic Details
Main Authors: Warintorn Ruksiriwanich, Jiradej Manosroi, Masahiko Abe, Worapaka Manosroi, Aranya Manosroi
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053566561&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49785
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-49785
record_format dspace
spelling th-cmuir.6653943832-497852018-09-04T04:29:33Z 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid Warintorn Ruksiriwanich Jiradej Manosroi Masahiko Abe Worapaka Manosroi Aranya Manosroi Chemical Engineering Chemistry Physics and Astronomy The three crude extracts including Oryza sativa (bran) from supercritical carbon dioxide fluid (scCO2) process which gave the highest unsaturated fatty acid contents and biological activities including the antioxidative, tyrosinase inhibition, stimulation index on human normal skin fibroblast were selected from ten edible plants to prepare the semi-purified fractions. Fraction No. 3 of the O. sativa bran crude extract gave the highest content of unsaturated fatty acids and 5α-reductase (type 1) inhibition activity (5AR). Its linoleic acid (LN) and total unsaturated fatty acid (TUC) contents were significantly positive and linear correlated to 5AR on DU-145 cell line (at r of 1.00, p < 0.01). Its total phenolic contents and all biological activities also showed positive correlations to 5AR with r > 0.9 (p < 0.05). This study has demonstrated the potential of fraction No. 3 fractionated from the O. sativa bran crude extract prepared by scCO2to be developed as anti-androgenic alopecia products. © 2011 Elsevier B.V. 2018-09-04T04:18:03Z 2018-09-04T04:18:03Z 2011-11-01 Journal 08968446 2-s2.0-80053566561 10.1016/j.supflu.2011.07.017 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053566561&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49785
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Chemical Engineering
Chemistry
Physics and Astronomy
spellingShingle Chemical Engineering
Chemistry
Physics and Astronomy
Warintorn Ruksiriwanich
Jiradej Manosroi
Masahiko Abe
Worapaka Manosroi
Aranya Manosroi
5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
description The three crude extracts including Oryza sativa (bran) from supercritical carbon dioxide fluid (scCO2) process which gave the highest unsaturated fatty acid contents and biological activities including the antioxidative, tyrosinase inhibition, stimulation index on human normal skin fibroblast were selected from ten edible plants to prepare the semi-purified fractions. Fraction No. 3 of the O. sativa bran crude extract gave the highest content of unsaturated fatty acids and 5α-reductase (type 1) inhibition activity (5AR). Its linoleic acid (LN) and total unsaturated fatty acid (TUC) contents were significantly positive and linear correlated to 5AR on DU-145 cell line (at r of 1.00, p < 0.01). Its total phenolic contents and all biological activities also showed positive correlations to 5AR with r > 0.9 (p < 0.05). This study has demonstrated the potential of fraction No. 3 fractionated from the O. sativa bran crude extract prepared by scCO2to be developed as anti-androgenic alopecia products. © 2011 Elsevier B.V.
format Journal
author Warintorn Ruksiriwanich
Jiradej Manosroi
Masahiko Abe
Worapaka Manosroi
Aranya Manosroi
author_facet Warintorn Ruksiriwanich
Jiradej Manosroi
Masahiko Abe
Worapaka Manosroi
Aranya Manosroi
author_sort Warintorn Ruksiriwanich
title 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
title_short 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
title_full 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
title_fullStr 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
title_full_unstemmed 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
title_sort 5α-reductase type 1 inhibition of oryza sativa bran extract prepared by supercritical carbon dioxide fluid
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053566561&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49785
_version_ 1681423472568303616