Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

• Main Authors: Voravuth Somsak, Chairat Uthaipibull, Parichat Prommana, Somdet Srichairatanakool, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053530568&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50024
• Institution: Chiang Mai University

Background: Plasmodium vivax is the most prevalent cause of human malaria in tropical regions outside the African continent. The lack of a routine continuous in vitro culture of this parasite makes it difficult to develop specific drugs for this disease. To facilitate the development of anti-P. viva...