Effects of Curcuma spp. on P-glycoprotein function

• Main Authors: Chadarat Ampasavate, Uthai Sotanaphun, Panadda Phattanawasin, Nusara Piyapolrungroj
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77950867304&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50565
• Institution: Chiang Mai University

The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by...