Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids

Objectives: To evaluate the hematological profile, oxidative stress, and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids for 12 months. Design and methods: Twenty-one β-thalassemia/Hb E patients were given 2 capsules of 250 mg each of curcuminoids (a total of 500 mg)...

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Main Authors: Ruchaneekorn W. Kalpravidh, Noppadol Siritanaratkul, Praphaipit Insain, Ratiya Charoensakdi, Narumol Panichkul, Suneerat Hatairaktham, Somdet Srichairatanakool, Chada Phisalaphong, Eliezer Rachmilewitz, Suthat Fucharoen
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50591
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-505912018-09-04T04:42:42Z Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids Ruchaneekorn W. Kalpravidh Noppadol Siritanaratkul Praphaipit Insain Ratiya Charoensakdi Narumol Panichkul Suneerat Hatairaktham Somdet Srichairatanakool Chada Phisalaphong Eliezer Rachmilewitz Suthat Fucharoen Biochemistry, Genetics and Molecular Biology Objectives: To evaluate the hematological profile, oxidative stress, and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids for 12 months. Design and methods: Twenty-one β-thalassemia/Hb E patients were given 2 capsules of 250 mg each of curcuminoids (a total of 500 mg) daily for 12 months. Blood was collected every 2 months during treatment and 3 months after withdrawal and was determined for complete blood count, malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) in red blood cells (RBC), and non-transferrin bound iron (NTBI) in serum. Results: The increased oxidative stress in β-thalassemia/Hb E patients was shown by higher levels of MDA, SOD, GSH-Px in RBC, serum NTBI, and lower level of RBC GSH. Curcuminoids administration resulted in improvement of all the measured parameters as long as they were administered. After 3 months withdrawal of treatment, all parameters returned close to baseline levels. Conclusion: Curcuminoids may be used to ameliorate oxidative damage in patients with β-thalassemia/Hb E disease. © 2009 The Canadian Society of Clinical Chemists. 2018-09-04T04:42:42Z 2018-09-04T04:42:42Z 2010-03-01 Journal 00099120 2-s2.0-76749103354 10.1016/j.clinbiochem.2009.10.057 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76749103354&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50591
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Ruchaneekorn W. Kalpravidh
Noppadol Siritanaratkul
Praphaipit Insain
Ratiya Charoensakdi
Narumol Panichkul
Suneerat Hatairaktham
Somdet Srichairatanakool
Chada Phisalaphong
Eliezer Rachmilewitz
Suthat Fucharoen
Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
description Objectives: To evaluate the hematological profile, oxidative stress, and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids for 12 months. Design and methods: Twenty-one β-thalassemia/Hb E patients were given 2 capsules of 250 mg each of curcuminoids (a total of 500 mg) daily for 12 months. Blood was collected every 2 months during treatment and 3 months after withdrawal and was determined for complete blood count, malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) in red blood cells (RBC), and non-transferrin bound iron (NTBI) in serum. Results: The increased oxidative stress in β-thalassemia/Hb E patients was shown by higher levels of MDA, SOD, GSH-Px in RBC, serum NTBI, and lower level of RBC GSH. Curcuminoids administration resulted in improvement of all the measured parameters as long as they were administered. After 3 months withdrawal of treatment, all parameters returned close to baseline levels. Conclusion: Curcuminoids may be used to ameliorate oxidative damage in patients with β-thalassemia/Hb E disease. © 2009 The Canadian Society of Clinical Chemists.
format Journal
author Ruchaneekorn W. Kalpravidh
Noppadol Siritanaratkul
Praphaipit Insain
Ratiya Charoensakdi
Narumol Panichkul
Suneerat Hatairaktham
Somdet Srichairatanakool
Chada Phisalaphong
Eliezer Rachmilewitz
Suthat Fucharoen
author_facet Ruchaneekorn W. Kalpravidh
Noppadol Siritanaratkul
Praphaipit Insain
Ratiya Charoensakdi
Narumol Panichkul
Suneerat Hatairaktham
Somdet Srichairatanakool
Chada Phisalaphong
Eliezer Rachmilewitz
Suthat Fucharoen
author_sort Ruchaneekorn W. Kalpravidh
title Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
title_short Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
title_full Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
title_fullStr Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
title_full_unstemmed Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids
title_sort improvement in oxidative stress and antioxidant parameters in β-thalassemia/hb e patients treated with curcuminoids
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76749103354&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50591
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