Pairwise decomposition of residue interaction energies of single chain Fv with HIV-1 p17 epitope variants

• Main Authors: Vannajan Sanghiran Lee, Panthip Tue-ngeun, Sawitree Nangola, Kuntida Kitidee, Jitrayut Jitonnom, Piyarat Nimmanpipug, Supat Jiranusornkul, Chatchai Tayapiwatana
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=74849100500&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50598
• Institution: Chiang Mai University

Computational assisted modeling was carried out to investigate the importance of specific residues in the binding site of scFv. In this study, scFv against HIV-1 epitope at the C-terminal on p17 (scFv anti-p17) was used as a candidate molecule for evaluating the method. The wild-type p17 and its nin...