Severe developmental bone phenotype in ClC-7 deficient mice

• المؤلفون الرئيسيون: A. V. Neutzsky-Wulff, N. A. Sims, C. Supanchart, U. Kornak, D. Felsenberg, I. J. Poulton, T. J. Martin, M. A. Karsdal, K. Henriksen
• التنسيق: دورية
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology
• الوصول للمادة أونلاين: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955279416&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50623
• المؤسسة: Chiang Mai University

Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteocla...