Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles

• Main Authors: Jiraphan Junjhon, Thomas J. Edwards, Utaiwan Utaipat, Valorie D. Bowman, Heather A. Holdaway, Wei Zhang, Poonsook Keelapang, Chunya Puttikhunt, Rushika Perera, Paul R. Chipman, Watchara Kasinrerk, Prida Malasit, Richard J. Kuhn, Nopporn Sittisombut
• Format: Journal
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954972691&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50924
• Institution: Chiang Mai University

During dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular pa...