Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction

• Main Authors: Jiraphan Junjhon, Matthawee Lausumpao, Sunpetchuda Supasa, Sansanee Noisakran, Adisak Songjaeng, Prakaimuk Saraithong, Kridsada Chaichoun, Utaiwan Utaipat, Poonsook Keelapang, Amornrat Kanjanahaluethai, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit, Nopporn Sittisombut
• Other Authors: Chiang Mai University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19281
• Institution: Mahidol University

In the generation of flavivirus particles, an internal cleavage of the envelope glycoprotein prM by furin is required for the acquisition of infectivity. Unlike cleavage of the prM of other flaviviruses, cleavage of dengue virus prM is incomplete in many cell lines; the partial cleavage reflects the...