Alterations of pr-M Cleavage and Virus Export in pr-M Junction Chimeric Dengue Viruses

• Main Authors: Poonsook Keelapang, Roongtawan Sriburi, Sanpaechuda Supasa, Nantaya Panyadee, Adisak Songjaeng, Aroonroong Jairungsri, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit, Nopporn Sittisombut
• Other Authors: Thailand National Center for Genetic Engineering and Biotechnology
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21398
• Institution: Mahidol University

During the export of flavivirus particles through the secretory pathway, a viral envelope glycoprotein, prM, is cleaved by the proprotein convertase furin; this cleavage is required for the subsequent rearrangement of receptor-binding E glycoprotein and for virus infectivity. Similar to many furin s...