Inhibition of cholinesterase by essential oil from food plant

Inhibition of cholinesterase has attracted much attention recently because of its potential for the treatment of Alzheimer's disease. In this work, the anticholinesterase activities of plant oils were investigated using Ellman's colorimetric method. The results indicate that essential oils...

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Main Authors:	Wantida Chaiyana, Siriporn Okonogi
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861835434&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51388
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-51388
record_format	dspace
spelling	th-cmuir.6653943832-513882018-09-04T06:13:18Z Inhibition of cholinesterase by essential oil from food plant Wantida Chaiyana Siriporn Okonogi Biochemistry, Genetics and Molecular Biology Medicine Pharmacology, Toxicology and Pharmaceutics Inhibition of cholinesterase has attracted much attention recently because of its potential for the treatment of Alzheimer's disease. In this work, the anticholinesterase activities of plant oils were investigated using Ellman's colorimetric method. The results indicate that essential oils obtained from Melissa officinalis leaf and Citrus aurantifolia leaf showed high acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. C. aurantifolia leaf oil revealed in this study has an IC50value on acetylcholinesterase and butyrylcholinesterase of 139 ± 35 and 42 ± 5 μg/ml, respectively. GC/MS analysis revealed that the major constituents of C. aurantifolia leaf oil are monoterpenoids including limonene, l-camphor, citronellol, o-cymene and 1,8-cineole. © 2012 Elsevier GmbH. All rights reserved. 2018-09-04T06:01:09Z 2018-09-04T06:01:09Z 2012-06-15 Journal 1618095X 09447113 2-s2.0-84861835434 10.1016/j.phymed.2012.03.010 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861835434&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51388
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Medicine Pharmacology, Toxicology and Pharmaceutics Wantida Chaiyana Siriporn Okonogi Inhibition of cholinesterase by essential oil from food plant
description	Inhibition of cholinesterase has attracted much attention recently because of its potential for the treatment of Alzheimer's disease. In this work, the anticholinesterase activities of plant oils were investigated using Ellman's colorimetric method. The results indicate that essential oils obtained from Melissa officinalis leaf and Citrus aurantifolia leaf showed high acetylcholinesterase and butyrylcholinesterase co-inhibitory activities. C. aurantifolia leaf oil revealed in this study has an IC50value on acetylcholinesterase and butyrylcholinesterase of 139 ± 35 and 42 ± 5 μg/ml, respectively. GC/MS analysis revealed that the major constituents of C. aurantifolia leaf oil are monoterpenoids including limonene, l-camphor, citronellol, o-cymene and 1,8-cineole. © 2012 Elsevier GmbH. All rights reserved.
format	Journal
author	Wantida Chaiyana Siriporn Okonogi
author_facet	Wantida Chaiyana Siriporn Okonogi
author_sort	Wantida Chaiyana
title	Inhibition of cholinesterase by essential oil from food plant
title_short	Inhibition of cholinesterase by essential oil from food plant
title_full	Inhibition of cholinesterase by essential oil from food plant
title_fullStr	Inhibition of cholinesterase by essential oil from food plant
title_full_unstemmed	Inhibition of cholinesterase by essential oil from food plant
title_sort	inhibition of cholinesterase by essential oil from food plant
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861835434&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51388
_version_	1681423760767320064

Inhibition of cholinesterase by essential oil from food plant

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