Cytostatic effect of xanthone-loaded mPEG-b-p(HPMAm-Lac 2) micelles towards doxorubicin sensitive and resistant cancer cells

• Main Authors: Ruttiros Khonkarn, Samlee Mankhetkorn, Marina Talelli, Wim E. Hennink, Siriporn Okonogi
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Chemistry; Physics and Astronomy
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859157763&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51394
• Institution: Chiang Mai University

Xanthone exhibits several medicinal activities and especially it inhibits the growth of cancer cells. However, the use of xanthone is limited because of its low aqueous solubility and systemic toxicity. In the present study xanthone was loaded into poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) me...