Aristolactam-type alkaloids from orophea enterocarpa and their cytotoxicities

Aristolactam-type alkaloids from orophea enterocarpa and their cytotoxicities

A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data....

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Bibliographic Details
Main Authors: Sanchai Nayyatip, Pak Thaichana, Mongkol Buayairaksa, Wirote Tuntiwechapikul, Puttinan Meepowpan, Narong Nuntasaen, Wilart Pompimon
Format: Journal
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Chemistry
Computer Science
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860116503&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/51410
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Institution: Chiang Mai University
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Summary:A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 μM, respectively. © 2012 by the authors.

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