Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance

• المؤلفون الرئيسيون: Pornsiri Pitchakarn, Shinobu Ohnuma, Komsak Pintha, Wilart Pompimon, Suresh V. Ambudkar, Pornngarm Limtrakul
• التنسيق: دورية
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Medicine; Nursing
• الوصول للمادة أونلاين: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=83355172162&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51431
• المؤسسة: Chiang Mai University

Multidrug resistance (MDR) is a major factor in the failure of chemotherapy in cancer patients. Resistance to chemotherapy has been correlated to the overexpression of ABC drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. Our previous st...