Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhi...

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Main Authors:	Ruangrat Choommongkol, Rattana Jongkol, Samran Prabpai, Palangpon Kongsaeree, Puttinan Meepowpan
Format:	Journal
Published:	2018
Subjects:	Chemical Engineering Chemistry
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860307253&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51462
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-51462
record_format	dspace
spelling	th-cmuir.6653943832-514622018-09-04T06:03:12Z Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps Ruangrat Choommongkol Rattana Jongkol Samran Prabpai Palangpon Kongsaeree Puttinan Meepowpan Chemical Engineering Chemistry Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC50values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved. 2018-09-04T06:02:13Z 2018-09-04T06:02:13Z 2012-03-15 Journal 1362511X 09574166 2-s2.0-84860307253 10.1016/j.tetasy.2012.03.006 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860307253&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51462
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Chemical Engineering Chemistry
spellingShingle	Chemical Engineering Chemistry Ruangrat Choommongkol Rattana Jongkol Samran Prabpai Palangpon Kongsaeree Puttinan Meepowpan Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
description	Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC50values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved.
format	Journal
author	Ruangrat Choommongkol Rattana Jongkol Samran Prabpai Palangpon Kongsaeree Puttinan Meepowpan
author_facet	Ruangrat Choommongkol Rattana Jongkol Samran Prabpai Palangpon Kongsaeree Puttinan Meepowpan
author_sort	Ruangrat Choommongkol
title	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_short	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_full	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_fullStr	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_full_unstemmed	Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
title_sort	synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem michael addition-dieckmann condensation reactions as the key steps
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860307253&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/51462
_version_	1681423774099963904

Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

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