Pharmacogenetic markers of CYP2B6 associated with efavirenz plasma concentrations in HIV-1 infected Thai adults

• Main Authors: Chonlaphat Sukasem, Tim R. Cressey, Pattamawan Prapaithong, Yardpiroon Tawon, Ekawat Pasomsub, Chutatip Srichunrusami, Thawinee Jantararoungtong, Marc Lallement, Wasun Chantratita
• Format: Journal
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84869010225&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51830

Aims: To investigate the frequency of CYP2B6 polymorphisms and the influence of haplotype structure on plasma efavirenz concentrations in Thai adults with HIV-1 infection. Methods: Genotyping of nine single nucleotide polymorphisms (SNPs, c.64C>T, c.499C>G, c.516G>T, c.785A>G, c.1375A>...