Calcium-induced Cardiac Mitochondrial Dysfunction Is Predominantly Mediated by Cyclosporine A-dependent Mitochondrial Permeability Transition Pore

• Main Authors: Chontida Yarana, Jirapas Sripetchwandee, Jantira Sanit, Siriporn Chattipakorn, Nipon Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866143717&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51868
• Institution: Chiang Mai University

Background and Aims: Cardiac mitochondrial Ca2+overload plays a critical role in mechanical and electrical dysfunction leading to cardiac cell death and fatal arrhythmia. Because Ca2+overload is related to mitochondrial permeability transition, reactive oxygen species (ROS) production and membrane p...