Reactive center loop moiety is essential for the maspin activity on cellular invasion and ubiquitin-proteasome level

• Main Authors: Chakkrit Khanaree, Kongthawat Chairatvit, Sittiruk Roytrakul, Ariyaphong Wongnoppavich
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880309087&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52227
• Institution: Chiang Mai University

Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo. The tumor-suppressing effects of maspin depend in part on its ability to enhance cell adhesion to extracellular matrix. Although the molecular mechanism of maspin's action is still u...