Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

• Main Authors: Jirapas Sripetchwandee, Jantira Sanit, Nipon Chattipakorn, Siriporn C. Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873713188&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52264
• Institution: Chiang Mai University

Aims Although iron overload induces oxidative stress and brain mitochondrial dysfunction, and is associated with neurodegenerative diseases, brain mitochondrial iron uptake has not been investigated. We determined the role of mitochondrial calcium uniporter (MCU) in brain mitochondria as a major rou...