Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol

• Main Authors: Orawan Wonganan, Chainarong Tocharus, Chonticha Puedsing, Sureeporn Homvisasevongsa, Oratai Sukcharoen, Apichart Suksamrarn
• Format: Journal
• Published: 2018
• Subjects: Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875987038&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52400
• Institution: Chiang Mai University

Isosteviol (1) has been reported to exhibit moderate vasorelaxant activity. In order to enhance the bioactivity of this compound, chemical modification of 1 to the dihydro analog, ent-16β-hydroxybeyeran-19-oic acid (2), was undertaken. Compound 2 was then converted to the corresponding acetate deriv...