Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)

From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5- Trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3- Trimethoxy-4,5- dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structu...

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Main Authors:	Wuttikrai Sesang, Sittiporn Punyanitya, Siripit Pitchuanchom, Phansuang Udomputtimekakul, Narong Nuntasaen, Ratana Banjerdpongchai, Benjawan Wudtiwai, Wilart Pompimon
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904787784&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53283
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-53283
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spelling	th-cmuir.6653943832-532832018-09-04T10:00:40Z Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib) Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5- Trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3- Trimethoxy-4,5- dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC50values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC50levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively. 2018-09-04T09:46:21Z 2018-09-04T09:46:21Z 2014-01-01 Journal 14203049 2-s2.0-84904787784 10.3390/molecules19078762 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904787784&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53283
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
description	From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5- Trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3- Trimethoxy-4,5- dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and 2 exhibited cytotoxic activity with IC50values of 26.36 ± 5.18 μM and 12.88 ± 2.49 μM, respectively, for human hepatocellular carcinoma HepG2 cells, and 64.75 ± 4.45 and 67.06 ± 3.5 μM, respectively, for human breast cancer MDA-MB231 cells. Both compounds displayed anti-cancer activity but less than that of doxorubicin; a conventional chemotherapeutic drug, the IC50levels of which were 2.21 ± 1.72 and 1.83 ± 0.09 μM for HepG2 and MDA-MB231 cells, respectively.
format	Journal
author	Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon
author_facet	Wuttikrai Sesang Sittiporn Punyanitya Siripit Pitchuanchom Phansuang Udomputtimekakul Narong Nuntasaen Ratana Banjerdpongchai Benjawan Wudtiwai Wilart Pompimon
author_sort	Wuttikrai Sesang
title	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_short	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_full	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_fullStr	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_full_unstemmed	Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)
title_sort	cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (craib)
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904787784&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53283
_version_	1681424106418864128

Cytotoxic aporphine alkaloids from leaves and twigs of pseuduvaria trimera (Craib)

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