Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads

Objective: This study was investigating the anti-cancer activity of rutin encapsulated in non-amidated low methoxyl pectin bead in various formulations with or without sorbitol and/or sodium bicarbonate (NaHCO3).Methods: The rutin beads formulations including 3NA (3% Non-amidated LMP), 3NA15Sor (3%...

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Main Authors: Pensak Jantrawut, Hiroyuki Akazawa, Warintorn Ruksiriwanich
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/53893
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-538932018-09-04T10:00:30Z Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads Pensak Jantrawut Hiroyuki Akazawa Warintorn Ruksiriwanich Pharmacology, Toxicology and Pharmaceutics Objective: This study was investigating the anti-cancer activity of rutin encapsulated in non-amidated low methoxyl pectin bead in various formulations with or without sorbitol and/or sodium bicarbonate (NaHCO3).Methods: The rutin beads formulations including 3NA (3% Non-amidated LMP), 3NA15Sor (3% Non-amidated LMP with 15% Sorbitol), 3NA1Bica (3% Non-amidated LMP with 1% NaHCO3) and 3NA15Sor1Bica (3% Non-amidated LMP with 15% Sorbitol and 1% NaHCO3) were prepared and the in vitro anti-cancer activities in 3 human cancer cell lines were investigated. Results: All beads were oblong or spherical shape with around 600 μm size. 3NA15Sor1Bica rutin bead composing both sorbitol and NaHCO3 exhibited higher cytotoxic activity with cancer cell viability were 51.41 ± 7.01 and 55.12 ± 3.96% on HT-29 and KB cells, respectively. There was no significant different (p>0.05) of cell viability between all bead formulation for HepG2 cells. Conclusion: These results confirmed that encapsulation of rutin in pectin beads exhibited their anti-cancer activity and can be applied for further human cancer treatment formulation. 2018-09-04T10:00:30Z 2018-09-04T10:00:30Z 2014-01-01 Journal 09751491 2-s2.0-84898485136 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898485136&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/53893
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Pensak Jantrawut
Hiroyuki Akazawa
Warintorn Ruksiriwanich
Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
description Objective: This study was investigating the anti-cancer activity of rutin encapsulated in non-amidated low methoxyl pectin bead in various formulations with or without sorbitol and/or sodium bicarbonate (NaHCO3).Methods: The rutin beads formulations including 3NA (3% Non-amidated LMP), 3NA15Sor (3% Non-amidated LMP with 15% Sorbitol), 3NA1Bica (3% Non-amidated LMP with 1% NaHCO3) and 3NA15Sor1Bica (3% Non-amidated LMP with 15% Sorbitol and 1% NaHCO3) were prepared and the in vitro anti-cancer activities in 3 human cancer cell lines were investigated. Results: All beads were oblong or spherical shape with around 600 μm size. 3NA15Sor1Bica rutin bead composing both sorbitol and NaHCO3 exhibited higher cytotoxic activity with cancer cell viability were 51.41 ± 7.01 and 55.12 ± 3.96% on HT-29 and KB cells, respectively. There was no significant different (p>0.05) of cell viability between all bead formulation for HepG2 cells. Conclusion: These results confirmed that encapsulation of rutin in pectin beads exhibited their anti-cancer activity and can be applied for further human cancer treatment formulation.
format Journal
author Pensak Jantrawut
Hiroyuki Akazawa
Warintorn Ruksiriwanich
author_facet Pensak Jantrawut
Hiroyuki Akazawa
Warintorn Ruksiriwanich
author_sort Pensak Jantrawut
title Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
title_short Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
title_full Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
title_fullStr Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
title_full_unstemmed Anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
title_sort anti-cancer activity of rutin encapsulated in low methoxyl pectin beads
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898485136&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/53893
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