Efavirenz concentrations and probability of HIV replication in children

Efavirenz concentrations and probability of HIV replication in children

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administra...

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Bibliographic Details
Main Authors: Nontiya Homkham, Tim R. Cressey, Naïm Bouazza, Chulapong Chanta, Linda Aurpibul, Thition Narkbunnam, Sawitree Krikajornkitti, Nareerat Kamonpakorn, Marc Lallemant, Lily Ingsrisawang, Nicolas Salvadori, Jean Marc Treluyer, Saik Urien, Gonzague Jourdain
Format: Journal
Published: 2018
Subjects:
Medicine
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84944217669&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/54817
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Institution: Chiang Mai University
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Summary:Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C12 below target threshold (<1.0 mg/L) with a 23% risk of viral replication.

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