Efavirenz concentrations and probability of HIV replication in children
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administra...
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2018
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th-cmuir.6653943832-548172018-09-04T10:24:09Z Efavirenz concentrations and probability of HIV replication in children Nontiya Homkham Tim R. Cressey Naïm Bouazza Chulapong Chanta Linda Aurpibul Thition Narkbunnam Sawitree Krikajornkitti Nareerat Kamonpakorn Marc Lallemant Lily Ingsrisawang Nicolas Salvadori Jean Marc Treluyer Saik Urien Gonzague Jourdain Medicine Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C12 below target threshold (<1.0 mg/L) with a 23% risk of viral replication. 2018-09-04T10:24:09Z 2018-09-04T10:24:09Z 2015-01-01 Journal 15320987 08913668 2-s2.0-84944217669 10.1097/INF.0000000000000854 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84944217669&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54817 |
| institution |
Chiang Mai University |
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Thailand |
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Medicine |
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Medicine Nontiya Homkham Tim R. Cressey Naïm Bouazza Chulapong Chanta Linda Aurpibul Thition Narkbunnam Sawitree Krikajornkitti Nareerat Kamonpakorn Marc Lallemant Lily Ingsrisawang Nicolas Salvadori Jean Marc Treluyer Saik Urien Gonzague Jourdain Efavirenz concentrations and probability of HIV replication in children |
| description |
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C12 below target threshold (<1.0 mg/L) with a 23% risk of viral replication. |
| format |
Journal |
| author |
Nontiya Homkham Tim R. Cressey Naïm Bouazza Chulapong Chanta Linda Aurpibul Thition Narkbunnam Sawitree Krikajornkitti Nareerat Kamonpakorn Marc Lallemant Lily Ingsrisawang Nicolas Salvadori Jean Marc Treluyer Saik Urien Gonzague Jourdain |
| author_facet |
Nontiya Homkham Tim R. Cressey Naïm Bouazza Chulapong Chanta Linda Aurpibul Thition Narkbunnam Sawitree Krikajornkitti Nareerat Kamonpakorn Marc Lallemant Lily Ingsrisawang Nicolas Salvadori Jean Marc Treluyer Saik Urien Gonzague Jourdain |
| author_sort |
Nontiya Homkham |
| title |
Efavirenz concentrations and probability of HIV replication in children |
| title_short |
Efavirenz concentrations and probability of HIV replication in children |
| title_full |
Efavirenz concentrations and probability of HIV replication in children |
| title_fullStr |
Efavirenz concentrations and probability of HIV replication in children |
| title_full_unstemmed |
Efavirenz concentrations and probability of HIV replication in children |
| title_sort |
efavirenz concentrations and probability of hiv replication in children |
| publishDate |
2018 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84944217669&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/54817 |
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