Iron distribution and histopathological study of the effects of deferoxamine and deferiprone in the kidneys of iron overloaded β-thalassemic mice

• Main Authors: Paranee Yatmark, Noppawan Phumala Morales, Urai Chaisri, Surasak Wichaiyo, Warinkarn Hemstapat, Somdet Srichairatanakool, Saovaros Svasti, Suthat Fucharoen
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991833270&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55156
• Institution: Chiang Mai University

© 2016 Elsevier GmbH Renal glomerular and tubular dysfunctions have been reported with high prevalence in β-thalassemia. Iron toxicity is implicated in the kidney damage, which may be reversed by iron chelation therapy. To mimic heavy iron overload and evaluate the efficacy of iron chelators in the...